YEVPATORIA
YEVPATORIA
Eupatoria; al. Gemeiner Wasserdost;
English
. Hemp
agrimony
.
Herb.
The herbaceous plant big, lively,
has
opposed leaves divided into three or five leaflets and jagged sharp reminder that the
Indian
hemp. The flowers, pink or
red
, tubular, chapters are grouped in small (<05 cm) which in turn are grouped in
a
compound curds.
Source
.
The
yevpatoriya
,
a
native of
central
Europe is
a
very
common
plant. It grows in bulk form dense populations in the gutters and rose
garden
on the edge of the creeks in the malls, along with hedges and in the humid forest fire.
Chemical composition.
This plant
has
resulted in numerous research studies. It
has
been shown the presence of triterpenes, acids and phenols poliínos. Among its many components,
has
been described an
essential
oil (0. 3%) flavonoids, derived benzodihidrofuránicos, esters of nerol and
a
clerodano (cannaclerodanólido, dilactona diterpene) 658] Also there are many alkaloids pirrolizidínicos both sides in the air (and its stereoisomers equinatina: licopsamina, intermedina, rinderina) and roots (supinina) It
was
also found Acetic acid esters,
angels
, tíglicos and isovaléricos [653, 656, 657] In the air bodies have been identified two polysaccharides, polymer heterogeneous xylose acid and 4 - O - methyl - glocurónico [659]
Sesquiterpenes lactones. These are mostly esters (4 - hydroxy - tiglate, tiglate. of 8ß - hydroxy germacranólidos: eupatoriopicrina (0. 4% in aerial parts) and its derivatives (19 - O - acetyl, 20 - deoxy, 3ß - hydroxy, 19 - O - linolenil) eupatólido. Other lactones have
a
similar structure: DERIVATIVE 3 - O - acetyl (eg cromolaénido, eucannabinólido) from 10. 14 - dehydro hydroxylated in 1 (sacalinina)
a
derivative of costunólido. The eupaquifolina
C
(
a
guayanólido) is the product of oxidation of eupatoriopicrina.
Pharmacological data.
Recognized as colerética, this drug
has
recently drawn
attention
to the properties of their cytostatic lactones.
Its activities colerética and hepatoprotective. We show that by administering parts of rat, iv 250 mg / kg produced
a
colerética. This is coleresis
home
hepatocitario as evidenced by the marked increase in clearance erythritol. It
was
also demonstrated in rats, hepatoprotective properties of the drug: its pre - emptive action with respect to the increase in transaminase (GPT) induced by CCI4 is identical (0, 25 - 1 g / kg) to that produced by the
thistle
seed marie (1 g / kg) The
yevpatoriya
is also salidiurético.
Cytotoxicity. In vitro, the eupatoriopicrina acts on HeLa cells and KB, on the human lung carcinoma (DI50 = 1. 5 mg / ml) as well as on other cells. This act seems lactone level
A
.
D
. N. In vivo, only
a
temporary slowing of the growth of solid
tumors
implanted in mice (3x20 mg / kg. Tumor Lewis)
Immunostimulant properties. Polysaccharides (10 - 2 - 10 - 5 g / 100 ml) stimulated phagocytosis of granulocyte and provide positive results in other tests used to determine this type of
activity
(chemiluminescence, clearance of
carbon
.
Employment.
There seems to have been carried out clinical trials in humans with this medicinal plant, and although most of the works "classic" of Pharmacognosy
almost
no mention of their use, some of them relate that in folk medicine, is used as colerética. In fact, that is collected from the first century before Christ
was
already used to relieve "diseases of the liver" and in Arabic medicine, is known as
a
diuretic. In the nineteenth century became
a
colerética usual. Today is not used much.
There
has
been no acute toxicity in mice with aqueous extract (2 g / kg,
The drug.
The leaves, divided into 3 - 5 segments, are opposed. The involvement of the chapters, cylindrical, is made up of bracts of unequal length: the external ones are shorter than domestic ones.
The flowers, pink and having ligules, are in
a
receptacle without scales: the style is always hairless. The achenes are black and free. In the absence of
a
formal method of control, you can conduct
a
study by CCF to verify the presence of lactones majority (revealing KMnO4) or the acidic phenols and flavonoids (UV and developer of difenilborato aminoethanol)
Bibliography.
H
. HENDRIKS, R. BOS and
A
.
P
. Bruins.
Analysis of the
essential
oil of Eupatorium cannabinum by com -
bined Gas Chromatography - mas spectrometry using electron im -
pact and negative ion chemical ionization.
Planta Med
. 51, 541 - 542, 1985.
H
. HENDRICKS,
T
. M. MALINGRÉ and
E
.
T
. ELEM.
Pyrrolizidine alkaloids, flavonoids and volatile compounds in.
the Eupatorium genus. Eupatorium cannabinum L. an ancient.
drug with new perspectives.
Pharm. Weekblad. 5, 281 - 286, 1983.
R. AQUINO, M. D'AGOSTINO, M. DOMESTIC,
F
.
SENA
-
And Tore O. SCHETTINO.
Flavonoid glycosides from Eupatorium cannabinum subsp. can -
nabinum.
Phytotherapy, 59, 236 - 238, 1988.
R. SIEBERTZ,
P
. Proksch, V. WRAY and L. WITTE.
Accumulation and BioSynthesis of benzofurans in root crops.
Eupatorium of cannabinum.
Phytochemistry, 28, 789 - 793, 1989.
H
. HENDRIKS, W. BALRAADJSING,
H
. J. HUIZINGA and
A
.
P
.
Bruins.
Investigation into the presence of pyrrolizidine alkaloids in Europe.
patorium cannabinum by means of positive and negative ion.
chemical ionization GC - MS.
Planta Med
. 53, 456 - 461, 1987.
H
. J. Huizinga,
F
. DE BOER,
H
. HENDRIKS, W. BALRAADJ -
SING and
A
.
P
. Bruins.
Positive and negative ion chemical ionization mass - spectrum.
metry of trimethylsilyl derivatives of pyrrolizidine alkaloids.
using NH + and OH - ions as the reactant.
Biomed. Environ. Mass Spectrom, 13, 293 - 298, 1986.
C
. ZDERO and
F
. BOHLMANN.
Eupatoriopicrin 19 - O - linolenoate and other constituents from.
Eupatorium cannabinum.
Planta Med
. 53, 169 - 172, 1987.
A
. Vollmer. W. SCHÄFER and
H
. WAGNER.
Immunologically active polysaccharide of Eupatorium canna -
binum and Eupatorium perfoliatum.
Phytochemistry, 25, 377 - 381, 1986.
H
. J. WOERDENBAG.
Eupatorium cannabinum L.
A
review emphasizing the SESQUI -
terpene lactones and their biological
activity
.
Pharm. Weekblad. 8, 245 - 251, 1986.
A
. LEXA, J. FLEURENTIN,
P
. R. Lehr,
F
. Mortier, M. PRU -
VOST and J. M. PELT.
Choleretic and hepatoprotective properties of Eupatorium can.
nabinum in the Rat.
Planta Med
. 55, 127 - 132, 1989.
H
. J. WOERDENBAG,
C
. MEIJER, N.
H
. MULDER,
E
. G.
E
. DE.
VRIES,
H
. HENDRIKS and
T
. M. MALINGRÉ.
Evaluation of the in vitro cytotoxicity of some Sesquiterpenes lac -
tones on
a
human lung carcinoma cells line using the fast - gre.
in dye exclusion assay.
Planta Med
. 52, 112 - 114, 1986.
H
. J. WOERDENBAG, W. LEMSTRA,
H
. HENDRIKS,
T
. M.
MALINGRÉ and
A
. W.
T
. Konings.
Investigation of the anti - tumor action of eupatoriopicrin.
Against the Lewis lung tumor.
Planta Med
. 53, 318 - 322, 1987.
H
. J. WOERDENBAG, J.
C
.
C
. VAN DER LINDE,
H
.
H
. KAM -
PING,
T
. M. MALINGRÉ and
A
. W.
T
. Konings.
Induction of DNA damage in cells by exposure to EAT - EUPAT.
riopicrin.
Planta Med
. 55, 101, 1989.
a
)
H
. WAGNER.
Immunostimulants from higher plants (recent advances) In:
Biologically active
natural
products,
K
. HOSTETTMANN and
P
. J.
LEA, ed. Oxford, Clarendon Press, 127 - 141, 1987.
b)
H
. WAGNER and
A
. Proksch, Immunostimulatory of drugs.
fungi and higher plants. In:
Economic and medicinal plant re -
search,
H
. WAGNER,
H
. HIKINO and N. R. FARNSWORTH, ed.
London, Academic Press, 1, 113 - 153, 1985.
A
. LEXA ROBIN.
Cholérétiques properties, antihépatotoxiques et diurétiques.
Eupatorium L. d'cannabinum:
approche - ethnopharmacologi.
than.
Doctoral Thesis, University of Metz (
Science
) Center des.
I'environnement of Sciences, Metz, 24 octobre 1988.
Diseases
whose treatment is appropriate in this plant.
Viral Hepatitis
.
Flu
.
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