Used Part
The rhizome, roots.
Active Principles
Alkaloids (1-1.5%) of steroid structure complex: Group yer-Veratrum: yervina (50% of the total alkaloids), veratramina and their glycosides (pseudoyervina, veratrosina). Ce-Veratrum Group: Protoveratrinas A and B.
Drug Action
Anxiety and presents an action strongly hypotensive. Parasiticide in topical use.
Indications
It is not recommended its use. (See section of precautions).
Externally has been used against scabies.
Caution / Poisoning
Not recommended for use due to the low therapeutic margin: the drug dose is very close to the toxic, which makes it very difficult to use either the plant, as its alkaloids.
The confusion with gentian has caused fatal accidents.
Vedegambre poisoning produces a blistering action on the gastrointestinal mucous membranes, with a great sense of burning, hypersecretion, nausea, vomiting, hypothermia, cold sweats, diarrhea and depression of cardiac and respiratory nerve centers, which can cause death.
Lethal dose (adult) = 2 grams of plant or 20 mg of veratrina.
Bibliography
Benigni, R; Capra, C; Cattorini, P. Piante Medicinali. Chimica, Pharmacology and Therapy. Milano: Inverni & Della Beffa, 1962, pp.1679-750 ..
Bézanger-Beauquesne, L; Pinkas, M; Torck, M. Dans la Plantes Les Thérapeutiques Moderne. 2. Paris: Maloine, 1986, pp. 435-6.
Bézanger-Beauquesne, L; Pinkas, M; Torck, M; Trotin, F. Medicinal plants of temperate Regions. Paris: Maloine, 1980, pp. 58-9.
Bruneton, J. Elements of Phytochemistry and Pharmacognosy. Zaragoza: Acribia, 1991, pp. 537-8.
Fernandez, M; Nieto, A. Medicinal Plants. Pamplona: Ediciones Universidad de Navarra, 1982, pp. 177; 235.
Paris, RR; Moyse, M. Summary of Matter Médicale. Take II. Paris: Masson, 1967, pp. 36-41.
Rivera, D; Obon, C. The Guide INCAFE of useful and Poisonous Plants of the Iberian Peninsula and the Balearics. Madrid: INCAFE, 1991, pp.179; 1094-5.
Samuelsson G. Drugs of Natural Origin. A Textbook of Pharmacognosy. Stockholm: Swedish Pharmaceutical Press, 1992, pp. 287; 291; 292.
Trease, GE, Evans, WCh. Pharmacognosy. Mexico City: Inter - MacGraw-Hill, 1991, p. 689.
Van Hellemont, J. Compendium of Phytothérapie. Bruxelles: Association Pharmaceutique Belge, 1986, pp. 420-1.
Villar, L; Palacín, JM; Calvo, C. Gomez, D; Montserrat, G. Medicinal Plants of the Aragonese Pyrenees and other tierrras Huesca. 2. Huesca: Provincial, 1992, p. 272.
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