; al. Teufelskralle;
. Devil's claw.
Harpagophytum procumbens is
perennial herbaceous plant with opposite leaves and large florets
persistent. The fruit is
woody capsule bearing
crown of hooks metallics that have given the popular name of "devil's claw, " hooks or hooks.
The plant is
to the southern African continent (between 15 and 30 degrees south latitude) grows spontaneously in the areas bordering the Kalahari Desert (Namibia, Botswana and South Africa in Cape Province and Transvaal) where they are concentrated around watering points.
In addition to non -
chemical components: estaquiosa (
tetraholósido) and other sugars,
, waxes, phytosterols free and combined, pentacyclic triterpenes free and esterified (Ursan and oleananos) amino acids, flavonoids and acids phenols, phenolic glycosides (verbascósido, isoacteósido) quinone, drugs containing glucosides monoterpenes in the series of iridoides that is attributed to the
• Iridoides. The constitutional majority is the harpagósido. This glucoside is hydrolyzed in mild conditions, harpagogenina in
very unstable molecule ciclopentenílica dialdehídica; this Genina
its hydroxyl in 8 esterified by Cinnamic acid. In the case of the hydroxyl harpágido is free. The drug also contains procúmbido (characterized by the presence of an oxirane) procumbósido (anhydrous is
derivative - 3, 6 for the procúmbido) and esters
- cumare in 8 of harpágido and 6 'of procúmbido. The average content of the drug in heterósidos dried varies from 0. 5 to 3%.
The harpagósido hydrolyzed by the emulsina and the aqueous extract of the drug is as effective as phenylbutazone in
, with connective tissue proliferation, induced by formaldehyde. The harpagósido, for its part,
demonstrated anti - inflammatory properties in the trial of the
oil in rat. These positive results were confirmed in an inflammatory semicrónica model. The harpagósido is weakly analgesic. The iridoides of
(especially the harpagogenina) have inhibitory effects on isolated guinea pig ileum, spurred by several agonists, all of the effects comparable to those exercised by nonsteroidal anti - inflammatory drugs on the same preparation,
not been possible to demonstrate any
at the waterways in the lipoxygenase and cyclooxygenase  It
also demonstrated the
of methanol extract raw  The analogy of the structural harpagogenina with prostaglandins could perhaps explain its biological
Observations on the Man.
Various studies show the beneficial effects of
large study conducted with 600 patients artrósicos,
shown that using high doses of the roots of
administered over several months, reflecting an improvement with an effectiveness rate that varies from 42 to 85% depending on the type of
of the knee, hands, back, lumbar. Other researchers confirm that
treatment is effective as per you about pain and
on the articular. Other works refer to the administration of peri - articular injection in the treatment of
The literature suggests the possibility of an interest in the case of
. The absence of side effects and
gastric allow the consumption of the drug for long periods, alone or in combination with other drugs, allowing lower doses usually recommended. For other information referred to by some authors (
, blood glucose lowering) it seems that there is no experience that allows pharmacological deny or confirm them. The drug is used in infusion or decoction and capsules (criomolido powder, extract, nebulized) The drug
no toxicity (LD50, ip, mouse: harpagósido, 1 g / kg; harpágido, 3. 2 g / kg; absence of pathological effects after administration of 7. 5 g / kg / day in rats semicrónica)
In Spain authorizing the use of this plant for
pain, inflammation processes joints, gout.
Not recommended for patients suffering from
- duodenal ulcers. It can produce mild discomfort in sensitive individuals, especially at high doses. Not be used during
and lactation. It can produce
in people hypersensitive.
The drug consists of the
roots tuberizadas (sometimes misnamed tubers) harvested in the wild. These roots, very rich in water, cut and dried. The fragments are presented in thick slices, in the form of
fan or rounded, or rudely pressed into disks. The fragments have
taste. The content glucoiridoides (colorimetric valuation, following the reaction of iridoides extracted with methanol, sulfuric with vanillin in the middle) should be higher than 2. 2% (This drug is registered in the Royal Spanish Pharmacopoeia since 1997) HPLC You can carry out an accurate assessment.
whose treatment is appropriate in this plant.