; al. Eleutherococus Wurzel;
, touch - me - not.
. senticosus is
thorny shrub (2 - 3 m) spanking leaves long petiolated. The flowers are grouped in umbels pentámeras simple, spherical, or associated only 2 or 3, supported by
stem inserted at the base of the leaf. The fruit is
black berry with 5 bones.
It is very abundant in eastern
, is also in Korea, China (Shanxi and Hubei) and Japan. Proliferates in the forests of hardwoods and cedars in the mountains and half in the plains. The roots of wild plants are harvested in late
Although the individual components of the drug have been called, mostly, "eleuterósidos" (0. 6 - 0. 9%) it is heterósidos Genina belong to groups whose very different phytochemicals:
eleuterósido (identical to daucosterol) acidic phenols: eleuterósido B (= glucoside
(glycosides of siringarresinol)
Ramna - arabinose oleanólico free acid (eleuterósidos I,
) or esterified by
trisaccharides (eleuterósidos L, M)
These compounds are very different from the ginsenosides. Have identified many other compounds in the roots of
: coumarin, lignans, fenilpropánicos derivatives (caffeic acid free and esterified,
coniferílico) beta - sitosterol, polysaccharides, 2. 5 to 3. 7%) simple sugars, vitamins, carotenes, pectin, waxes, fats, etc.
In 1986 the eleuteranos were purified, heterogeneous molecular
polysaccharides from 3 x 103 and 7 x 104 and identified their constituents dare. The leaves contain numerous saponosides triterpenic: the civujianósidos.
The drug is difficult to classify according to the standards of Western medicine: well, according to the authors Russians, it is
"adaptogens. " They respond to that term drugs that are harmless and do not
that increase the body's resistance and normalize the pathological situations. Therefore, it is sensitive to pharmacological or biological tests, bearing in mind also that really do not know the principles allegedly assets.
in tests conducted in experimental animals is the stimulant of the
(antihipnótico, rabbit) strengthens the resistance to fatigue (time swimming in the rat, by climbing
rope in the mouse. improves reaction to
(mouse subjected to thermal variations, immobilized rats, damage to chemical caterpillars) exerts
protective effect radio (mouse) and anti - inflammatory.
Other authors, after
trial in the long term (3 months) conducted in mice, found no effects "anti" attributed to the drugor not observed in rat biochemical changes expected. The eleuteranos exert hypoglycemic effects in
mice or when it causes
hyperglycemia with aloxano. In vitro tests show immunostimulants properties due to
polysaccharide fraction 
Observations on the Man.
The drug, known no doubt for the
shamans and used by Chinese medicine,
been the subject of numerous studies in humans whose results remain questionable because they are difficult to verify ": what can we conclude from the" remarks "Made during
rally car, in corridors where there is the" tone "or athletes of high level or even better in the cosmonauts? Literature of the clinical data can highlight an improvement of the physical results, especially among athletes, after
exercise  as well as people who perform work force.
The drug can be considered devoid of toxicity at the recommended doses in therapeutic: both the aqueous extract (3 g / kg, mouse, per os) and the infusion (25 ml / kg) manifested non - toxic. The LD50 of the extract to 33% ethanol is 23 ml / kg (toxicity due to ethanol? The drug is currently used in powder form criomolido, nebulized, hydroalcoholic extracts and teas. In healthy men, this "harmonizing"  recommended in various circumstances: as of
, anti - intellectual and physical fatigue,
, disruption of senescence. This last statement is very controversial and disputed 
In Spain, authorizing the use of this plant in case of convalescence,
, preparation of examination and testing sports.
The roots of
are fragmented and curved, often tortuous, rarely branched. The outer surface is greyish
, the cut is clean and displays
finely radiated midfield area, pale
, surrounded by
thin cortical zone,
. The characterization of the main components of the drug is made by CCF an ether extract (Genina products and low polar) and
methanol extract redisuelto in butanol (heterósidos) This technique allows to distinguish the
of the samples. The high - resolution
chromatography reversed phase can also appreciate some eleuterósidos.
N. R. FARNSWORTH,
. SOEJARTO and
status as an adaptogen. In: Economic and medicinal plant research,
. HIKINO et N. R. FARNSWORTH, eds. London, Academic Press, vol 1
. 155 - 215, 1985.
. WAGNER, Y.
. OBERMEIER, G. TITTEL and S. BLADT.
Die DC - und HPLC - Analyze der Eleutherococcus Drugs.
. 44, 193 - 198, 1982.
R. S. XU, S.
and Z. Y. FAN.
Studies on the polysaccharide of Acanthopanax senticosus.
. 39, 278 - 279, 1980.
Ä. Ï. Ó Baranov.
Medical uses of
and related plants in the Soviet Union; recent trends in the Soviet literature.
J. of Ethnopharmacology, 6, 339 - 353, 1982.
. HIKINO, M. TAKAHASHI,
. Otaka and
Isolation and hypoglycemic
and G: glycans of Eleutherococcus senticosus roots.
J. Nat. Prod. 49, 293 - 297, 1986.
The drug that builds Russians.
New Scientist, 576 - 580, 1980.
. LEWIS, V.
. Zeng and R. G. LYNCH.
No adaptogen response of mice to
and Eleutherococcus infusions.
J. of Ethnopharmacology, 8, 209 - 214, 1983.
. J. Stab.
The physiological effects of Aralia, Panax and Eleutherococcus on exercise Rats.
Japan J. Pharmacol. 35, 79 - 85, 1984.
Quelques nouvelles acquisitions dans le domaine scientifique et medical.
Act. Pharm. 245) 69 - 73, 1987.
J. L. Rouaud and
Preliminary Study of the toxicity of the Infus Eleuthérocoque of
. B. 709) 110, 1977.
. J. MEDON.
Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and
administration in mice.
Acta Pharmacol. Sin. 2, 281 - 285, 1981.
. And M. WAGNER - L - LOH.
MANN - MATHES.
Macrophage activation and induction of macrophage cytotoxicity by.
polysaccharide fractions purified from the plant
Immun. 46, 845 - 849, 1984.
. JOUSSELIN, R. Questel and
Eleuthérocoque experiment de l'au cours d'un cycle d'à dominant aerobic Training.
Kinesiology, 23) 97 - 103, 1984.
. Delaveau. Eleuthérocoque.
Act. Pharm. 210) 49 - 50, 1984.
. TAKAHASHI, M. Miyashita,
. Matsuzaka, S. Muramatsu, M. Kuboyama,
. KUGO and J. IMAI.
Effect of Eleutherococcus senticosus extract on human physical working capacity.
. 52, 175 - 177, 1986.
- J Shao, R. KASAI, J -
XU and O. Tanaka.
Saponins from leaves of Acanthopanax senticosus Harms. Ciwujia: ciwujianosides structures of B, C1, C2, C3, C4, D1, D2, and
Chem. Pharm. Bull. 36, 601 - 608, 1988.
whose treatment is appropriate in this plant.