Circulatory failure CEREBRAL
Circulatory failure CEREBRAL
It is defined as
insufficiency to the set of hemodinámicas disturbances of the
like an insufficiency of the
flow in the
of the brain. The upheavals of the perfusión of the
set of clinically different symptoms, according to the zone and the size of the affected
Generally, the appearance of
insufficiency is consequence of several phenomena. It is the conjunction of factors that diminish the caliber of the
network and of that they increase viscosity sanguineous. The etiologías are numerous.
The estenosante reach is in first term. These estenosis, to the margin of some malformations vasculares and
traumatismos, are originated generally by lipídicos upheavals: hiperlipidemia, hipercolesterolemia and hipertrigliceridemia.
In the long term,
too rich nourishing
and saturated fat contribution can cause ateromas. Nevertheless, it is not necessary to underestimate the presence of other factors of risk like:
• Upheavals of the coagulation.
• estrogénicas Deficiencies.
• sedentary Life.
• and some hereditary and ethnic factors.
insufficiency is translated in located painful signs in an encephalic
zone. Often, the clinical expression is moderated by the presence of an auxiliary
network, specially, the polygon of Willis that communicates the vertebrales arteries right and left. In order to illustrate the
insufficiency, one resorts generally to the description of
characteristic and individual forms
: the insufficiency to vértebro - basilar.
The symptoms are transitory, being mainly the following ones:
• Vertigos and upheavals of the balance favored by rotation of the head.
• optical Upheavals that can go from the simple blurred vision to the transitory bilateral o'culo - motor paralysis.
• recidivantes Migraines.
• Síncopes, lipotimias.
• Upheavals of the watch.
Nevertheless, during most of the time, the manifestations of the
insufficiency are more discreet, being translated in
reduction of the perfusión at more
The clinical signs settle progressively and insidiosamente. It is catalogued to them like psico - comportamentales upheavals of the
• upheavals of the behavior and humor.
• upheavals of the dream.
• upheavals of the memory and the conception of ideas.
• upheavals of the concentration,
and the watch.
These upheavals are the consequence of an alteration of the
Mechanisms of the alteration.
The investigators show
great interest in the molecular modifications, because these would explain the appearance of the observed cellular alterations during isquemia
. The reduced oxygen contribution causes numerous biochemical phenomena that cause
disfunción of the cellular metabolism.
Therefore, in case of hypoxia, the cells present / display upheavals of the permeability due to the opening of different ionic channels from membrane level. This causes
invasion in the cell. The massive calcic ion presence activates fosfolipasas that takes to
lisis of the phospholipids with severe disturbance of the membrane
, specially, of necessary protéicas enzymes for the maintenance of the ionic levels.
The lisis of the phospholipids provides free fatty acids of between which some of them will be metabolizarán in mediators.
These mediators, prostaglandins, leucotrienos and tromboxanos are the people in
of the observed injuries (edemas, microcirculatory upheavals) that produce free radicals. Of simultaneous form, the power
of the hipóxica cell causes an alteration of the oxidorreductor potential of mitocondrias, also favoring the production of free radicals and
reduction of the protective antirust agents (enzymes: catalasa, glutatión peroxidasa, superoxide dismutasa and vitamins)
The conjunction of these phenomena is translated in
of the free radicals on the membrane fatty acid chains that have double connections. The attacked fatty acids form lipoperóxidos toxic in the cell, whose presence in the
weave is well - known for
It is identified to them in pigment form like the lipofucsina. At level of the
cells, the lipídicas
are responsible for serious disturbances in the permeability of membranes, particularly, in the
of pumping of sodio / potasio and in the ionic force of the cytoplasm.
This is translated in deficiencies of the sináptica neurotransmisión. It it is come off, the implication of the free radicals in the isquémicos processes of involución and
It remembers that the size of
is of 7 µ and that the diameter of
small 3 capillary is of µ.
In order to arrive at the most distant level, the eritrocito must undergo
biconcave form that can be observed the microscope very easily. In case of diminution of the power of
hypoxia with the consequences that we finished seeing. Therefore, to conserve
correct physiological neuronal operation, it is important to maintain the flexibility of the eritrocitaria membrane.
This deformabilidad of the
is determined by numerous factors, specially, by the particular constitution of its membrane phospholipids.
These phospholipids lock up an important poliinsaturados fatty acid content of 20 and 22 carbons. These fatty acids can come directly from foods,
generally, are synthesized from nutritional fatty acids of 18 carbons (the calls
fatty acids) thanks to
enzymes able to extend to the chain
of coal from 18 to 20 or 22 (elongasas)
Nevertheless, the western feeding is poor in fatty acids of 20 and 22 carbons, that are those that improves the flexibility of membranes. This originates
weakening of the sintetizador power of enzymes, situation that is worsened with the age.
In the upheavals of the deformabilidad, it is then, of great interest the suplementación of the diet with
, present fatty acids in
In case of oxidation of membrane lipids, also they can appear alterations of the deformabilidad.
with oxidized lipids (lipoperóxido) presents / displays membrane
: extreme rigidity and forms cellular abnormal.
The oxidating phenomena must to the presence of toxic substances in the blood (
, some medicines) and of free radicals. The variation of the index of rigidity of
globules can be measured perfectly before the presence of these oxidating agents.
Therefore, it is of great interest to find molecules antirust that they protect the membrane of the eritrocito of the
of the free radicals.
, it is advised to eliminate the toxic factors before.
Carried out recent studies with
tree leaf have shown the unsuspected one to be able antirust of this plant on
Also, analyses of variation of the
deformabilidad have been made in two lots of
globules exposed an oxidating agent: the
. being stated that:
The first lot, not protected by the
peroxidation. The index of rigidity of these
multiplied by four.
glógulos of the second lot, protected by the
tree, conserved intact their deformabilidad with respect to the control (measured carried out by means of hemoreómetro)
protective action the membrane of
globules before the injurious peroxidations.
This antirust and protective power of the free radicals must to the oleuropeósido presence of in the leaf of the
tree, concretely, of the fraction hidroxitirosol of this molecule.
1. Hygienic -
Factors of risk.
The risk factors must be fought with
These factors are the following ones:
In order to avoid or to stabilize the aterosclerosis phenomena, it is fundamental to control the lipídico contribution.
1) Reducir the fat contribution to 20 or 30 % of the caloric total.
To reduce injurious fats (saturated or modified fatty acids) mantequilla, milky products, margarina, greasy meat (lamb, pig, charcutería) frituras, pastry shop.
form (fatty acids insaturados) and fished (fatty acids of long chain of 20 and 22 carbons)
2) Limitar the nourishing
300 mg / día (the equivalent one to an egg yolk)
To reduce the egg consumption, mantequilla, greasy cheeses, hunts, vísceras and crustaceans.
It is necessary to insist on the necessity to carry out
gymnastics. To practice intellectual activities: reading, party games.
, associated to hygienic -
rules, allows to treat the
insufficiency without toxicity nor indirect effect.
We would propose, first of all, regulating plants of the sanguineous flow of the brain, like
. Also we will return to speak of the
tree by its antirust and protective properties from the membrane of the
Plants adapted for this