Agranulocytosis

Disease information



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Agranulocytosis
Agranulocytosis.

Reducing the amount of normal white blood cells (granulocytes, or neutrophils) in the bloodstream.

These are the first cells that defend us from bacterial infections.

Can appear at any age in both sexes.

Causes.

Anyone who promotes the destruction or preventing the production of granulocytes (white blood cells)

The most common cause is an adverse reaction to medications or chemicals including:

anticancer drugs,

anticonvulsants,

antihistamines,

antitiroides drugs,

medicines with arsenic,

chloramphenicol,

dibenzapina,

gold salts,

indomethacin,

nitrofurantoin,

Nitric oxide,

fenotiacidas,

phenylbutazone,

procainamide,

sulfonamides,

synthetic penicillins and.

tiacídicos diuretics.

While not everyone can produce with the same probability.

Also occur after poisoning with industrial aromatic solvents such as benzene.

Signs and symptoms.

Fever.

Dolores.

Sore throat.

Ulcers (especially in the mouth and throat) that do not produce pus and will not heal alone. Any sign of infection in someone who has had agranulocytosis can be a symptom of relapse.

Risk Factors and Prevention.

Genetic factors. A rare form, infants, agranulocytosis, is hereditary.

Avoid relapses not taking any medicine or drug is suspected of having caused agranulocytosis earlier.

Do not take any medicine unless absolutely necessary.

Diagnosis and Treatment.

Diagnosis is made by history and physical examination by a doctor.

The history - making one of the drugs listed, or contact with chemicals commented is a great help to guide the diagnosis.

Usually require testing of blood, nose, throat, urine and bone marrow.

General Measures.

The hospitalization during the acute phase is usually necessary.

After hospitalization, we recommend:

Scrupulous personal hygiene.

Keep your mouth clean with frequent rinsing with warm water can salt, or gargle with hydrogen peroxide (hydrogen peroxide)

Be especially careful with your oral hygiene. Brush your teeth with a very soft brush, avoiding irritating gums.

Avoid contact with aggressive agents such as cleaning chemicals, glue, insecticides, fertilizers, turpentine and others.

Medication.

Your doctor can:

Prescribe oral or intravenous antibiotics if the counting of the cells is very low.

Prescribing lithium to stimulate bone marrow to produce more granulocytes.

Remove any drug suspected of causing agranulocytosis.

Activity.

Save your bed during the acute phase.

Go back to your normal activities when they cede the symptoms.

Complications.

Kidney damage.

Dangerous infections, sometimes fatal (bacterial, fungal, viral or other) resistant to treatment.

Tell your doctor if.

The following occurs after treatment:

Any sign of infection, especially fever.

Swollen feet and ankles.

Painful urination or reduction of urination in 1 day.

Presents new unexplained symptoms. The drugs used in treatment can cause side effects.

Forecast.

According to the cause, can be cured with intensive treatment.


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